Recipe for Health: Alas, A Simple Solution to Eating Well

I have previously mulled over the implications of treating health more like wealth. Today, I want to mull over the implications of treating health more like paella.

Don't worry--it will make sense in the end! If I may borrow from The Best Exotic Marigold Hotel, if it doesn't make sense, it's not yet the end.

It's a rare day that I don't do at least one interview about nutrition and dieting for a magazine, radio station, TV show, or website. In the weeks leading up to the holidays, the volume of such media requests only grows. We are, it seems, permanently preoccupied, and seasonally obsessed, with what to eat, how much, and how to fix the damage done when we get both of those wrong, as happens all too often.

The odd thing is not the number and frequency of these exchanges; I suppose, in a society struggling so to eat well and control its weight, that's perfectly understandable. The odd thing is that to justify so many stories in so many media outlets so much of the time, every one of them has to pick a different focus. Or, if you will, choose a different "active ingredient."

It might be cutting dietary fat--once, the far most popular approach to "dieting," then maligned as yesterday's news, if not misguided nonsense, and now back on the agenda, courtesy of at least one recent study in the British Medical Journal. And if that is the topic, I am asked: Does cutting fat help with weight loss? Is it good for health?

It might, instead, be cutting carbs--in the form of the original Atkins Diet, now often maligned as yesterday's news even by those who once embraced it, or an updated version of it that pays a bit more attention to varieties of fat. There's also the plant-based Eco-Atkins approach, or the true original: the Paleolithic Diet. And if that is the topic, I am asked: Does cutting carbs help with weight loss? Is it good for health?

It might be going vegetarian. It might be going Mediterranean. It might be lowering the glycemic load. Pick anything you like.

I don't pick any of these, actually. But we'll get back to that.

For now, imagine if, as a society, we were totally preoccupied not with cooking up good health and good looks, but, say ... paella. Let's pretend that what we all want to do is make the best darn paella possible (if that were the case, by the way, you'd be out of luck, because my wife's aunt is the winner!).

Well, then, I suppose every morning show and magazine would need to run stories about paella. And since those stories would need to be different enough from one another to justify their number and frequency, they would each have to pick a different ingredient.

There would be stories only about the rice. And those stories wouldn't mention any other ingredients, as if rice were all there was to it.

There would be stories about the saffron, which, of course, is crucial to good paella. But those stories would fail to mention any other ingredients, as if saffron could stand alone.

There would be stories about the mussels. There would be other stories about the shrimp; still others about the chicken; and others again about the peppers, peas, onions, tomatoes, and the chorizo (we leave chorizo out of ours, for what it's worth).

Your task, then, as the consumer of these stories, is to pick. But of course, you can't really pick. No matter how good the saffron, paella is not made of saffron alone. Nor of rice alone. No one ingredient does a paella make!

You need the whole recipe to make the dish, the quality of which will be a product of the quality of all of the ingredients. The "active" ingredient in paella is ... paella!

As silly as it might be to tell a tale of paella based on just one ingredient at a time, it would still be less silly than our prevailing approach to dietary health. Because there, we don't so much focus on one ingredient to include as we do about one ingredient to exclude. Most stories about diet, weight, and health are about what NOT to eat.

If we devoted ink and electrons to paella in this fashion, there would be stories about why not to put in blueberries, or macadamia nuts, or marshmallows. There could be infinite stories about what not to include in your paella--none of which would really help you make the stuff, would it?

For far too long, we have approached the recipe for health in just this way. I'm not really convinced that 2013 will be the year we stop, but I am at least permitting myself to hope so.

The recipe for eating well involves a variety of real foods, direct from nature, and generally with a shorter life expectancy than your own: vegetables, fruits, whole grains for those inclined, nuts and seeds, beans and lentils. It can include or exclude fish and seafood, some grass-fed lean meats, and organic poultry. It can include or exclude organic eggs and low-fat dairy.

The right recipe for health, like the right recipe for paella, isn't just right with regard to one ingredient--it's altogether good. Eating well is intrinsically rich in nutrients: vitamins, minerals, antioxidants, and fiber. Eating well is low in chemicals, refined starches, added sugars, sodium, and the harmful varieties of dietary fat. Eating well has a low glycemic load. Eating well does not require instructions to avoid foods that glow in the dark; that takes care of itself. In the same way that a good paella recipe naturally omits marshmallows and macadamia nuts, a good recipe for health doesn't need to declare exclusions.

And of course, good paella is delicious. A good diet for health should be, too. With an emphasis on healthful, wholesome ingredients, and the diverse ways to assemble them into a diet customized to your preferences, it should certainly be possible to wind up loving the food that loves your health back.

I practice what I'm preaching here. So, as noted, I don't cut fat or carbs or fructose. I don't focus on lowering my glycemic load or adding fiber. All of these matter--so I eat well, and this all takes care of itself. Including when I enjoy my aunt's paella!

That paella is deliciously defined by what's in it, not what's left out. And it is not just about one ingredient. It's a harmonious blend. The recipe for health is just the same.

Kevin Arpino Plays to a Silent Audience

TALL and tan with a wrist full of jangly silver bracelets, Kevin Arpino shouted into his cellphone in a room full of fashion models.

“We need black pipin’,” he said, his profundo basso voice twisted by Dunhill Internationals and a strong North London accent. “Pipin’!” he repeated.

His assistant on the other end didn’t understand. “Piping,” he added with urgency, stressing the “g.” “For the pillows.”

“Such is the price of being English,” he said, but the models didn’t crack a smile. They couldn’t. They were fiberglass.

Mr. Arpino, 60, was standing in the disarrayed showroom of Rootstein Display Mannequins in Chelsea, where he is the creative director. It was the eve of the Retail Design Collective, a three-day event in early December known informally as Mannequin Fashion Week. Showrooms across Manhattan parade new hands, torsos and life-size figures. And though these models can’t use Twitter or Instagram, there is glamour nonetheless.

The hot ticket was the unveiling of Mr. Arpino’s newest collections, which he presents every year in Rootstein’s showroom on West 19th Street. “This year, it’s going to be all black and white,” he said, his dark eyes glittering. “Just like a photograph.”

Brash and particular, Mr. Arpino, who wears only black and white year-round, is a polarizing and powerful figure in the land of plastic people. Some call him the emperor of the windows. His collections (he usually releases two a year) are bellwethers for the small, tight-knit industry.

Though few outside the industry know Mr. Arpino’s name, his work is seen at all retail levels, from high-end stores like Saks Fifth Avenue, Hermès, Lanvin, Chanel and Ralph Lauren, to mass brands like Zara, Juicy Couture and H & M.

Starting at $1,300, Rootstein mannequins aren’t cheap. The company manufactures 10,000 mannequins a year in factories in Tokyo, London and New York. “I refuse to manufacture in China,” Mr. Arpino said.

Rootstein was founded in 1959 by a South African window dresser living in London named Adel Rootstein. Her innovation wasn’t to cast celebrities as mannequins (Mary Brosnan had made mannequins of Babe Paley in the 1940s) but to use youthful models. Her 1966 mannequin of Twiggy remains a milestone.

Under Mr. Arpino’s stewardship, Rootstein’s collections have been theatrical and occasionally controversial. Previous collections have been devoted to sadomasochism, vegetables and “The Great Gatsby.” In 2010, Mr. Arpino came under fire for his Young and Restless collection, which featured hobbledehoys with 27-inch waists. The Guardian ran a piece headlined, “Skinny Male Mannequins Raise Eating Disorder Fears.”

Mr. Arpino remains unabashed. “If you want to blame someone, blame the designers,” he said, before adding, without apology, “Unfortunately, clothing looks better on tall and skinny people.”

For many shoppers, mannequins are the 50-something women of the fashion world: invisible in plain sight. But for Mr. Arpino, each is a person with a story. “I know all of these girls,” said Mr. Arpino, gently popping off the arm of a mannequin named Tamara. “She’s only 19. She was the runner-up for Miss Russia beauty pageant.”

The process of transforming a living model into a fiberglass mannequin takes a year and a half. Mr. Arpino not only oversees the highly technical production, but also the stylistic direction. It requires one to be finely attuned to seasonal trends — skinny jeans call for skinnier legs, higher heels for more relevéd feet.

Mr. Arpino typically holds castings during London Fashion Week in September. Models sit for hours in little more than a bikini over a three-week period at Rootstein’s studios in West Kensington. “Models are essentially just breathing mannequins,” he said. “So it’s not terribly difficult.”

There they are sculptured into life-size clay models as Mr. Arpino tweaks the poses. The clay models are then made into a mold and cast in fiberglass. “Look at these things,” Mr. Arpino said, knocking one of them hard on the sternum. “They last forever.”

The same could almost be said of Mr. Arpino, who has been in the business for 30 years. “One reason Adel picked me,” he said, “is because I knew who the good girls were because I had worked with them.”

Under his direction, mannequins have been made from Yasmin Le Bon, Dianne deWitt and Pat Cleveland. Recent models have included Agyness Deyn, Coco Rocha and Erin O’Connor. “If they can sell fashion in magazine, they can sell fashion in a store,” he said.

This had been an unusually busy season. Mr. Arpino unveiled three collections this month, which were displayed in various tableaus in his Chelsea showroom.

“These are from the collection Sojourners,” he said, pronouncing it as if it were French. The languid mannequins swanned in repose. “Models are the new Gypsies, you know. These girls are from Poland, Russia, Lithuania.”

The other collections were an abstract line, Lift, and another realistic one called Street Boys. The latter, homeless-seeming, were skinnier than the Sojourners and had scruffy stubble.

Mr. Arpino has shown a knack for identifying emerging beauty and capturing its ascent. But to stroll through the showroom is to acknowledge how fleeting that beauty is. ‘“That’s Irie. That’s Dianne. That’s Joe,” Mr. Arpino said, the mannequins looking as youthful as the day they were cast.

There’s one mannequin that Mr. Arpino has vowed never to make: of himself. “Years ago Adel asked,” he said. “But I’d prefer not. It’s just a little too Dorian Gray for my taste.”

Designer Antonio Azzuolo to Bring His Standout Ready-to-Wear Collection to Charleston Fashion Week 2013

Charleston Fashion Week®announces Antonio Azzuolo will join as a featured designer and a fashion panel member at CFW 2013 (March 19-23). Azzuolo, a 2011 CFDA/ Vogue Fashion Fund finalist and 2012 CFDA Swarovski Award for Menswear nominee, will present his Spring Summer 2013 collection, a.a. antonio azzuolo. He joins Fern Mallis and other fashion industry leaders on the CFW 2013 Fashion Panel, offering advice and mentorship to competitors in the Emerging Designer Competition: East.

a.a. antonio azzuolo, the custom, hand-tailored menswear collection, launched in 2008, drawing an immediate landslide of praise throughout the ranks of international fashion critics at The New York Times, GQ, Style.com, Esquire, and WWD, to name a few - for expert, razor-sharp tailoring alongside contrasting hints of whimsy and nods to street style. His Spring Summer 2013 included unisex pieces, proving he’s got something to appeal to every style.

“There’s a focus on what I do best, the tailored blazer and garment,” Azzuolo has said of his work. “I’m pleased to bring my collection to such a cultural hub as Charleston, and I look forward to being a part of Charleston Fashion Week®.”

Scheduled for March 19-23, 2013, Charleston Fashion Week® will continue its mission to serve as a pipeline to career success for undiscovered talent in fashion design. CFW, in its seventh year, offers aspiring designers exposure and mentorship from fashion industry leaders in addition to producing a professional runway show.

Charleston Fashion Week® 2013 takes place March 19 – 23, 2013. For more information on CFW, Antonio Azzuolo, CFW’s Emerging Designer Competition: East, and to purchase tickets, visit charlestonfashionweek.com. Find @ChasFashWeek on Twitter, Facebook, and Instagram.

About Charleston Fashion Week®

Showcasing fashion designers, retailers, and models, Charleston Fashion Week® has become one of the premier fashion weeks in North America. Named a Top 20 Event for March by the Southeast Tourism Society, this event presents runway shows, interactive entertainment, chic after-parties, and press events. The 2013 event will be held under the tents in Marion Square in Charleston, SC, featuring more than 45 runway shows, the Spring Bridal Show, Emerging Designer Competition: East, and Rock the Runway Model Competition™. Charleston Fashion Week® 2013 is scheduled for March 19-23. www.charlestonfashionweek.com.

Portuguese Model Murder: 20-Year-Old Convicted Of Killing 65-Year-Old Lover

The Portugese model murder in New York City has ended with a guilty verdict against Renato Seabra, the 20-year-old model who murdered 65-year-old lover Carlos Antonio De Castro. The murder between the two Portugese men occurred in their shared InterContinental Hotel room in Times Square almost one year ago.

According to Manhattan District Attorney Cyrus R. Vance Jr.:

“This was a brutal and sadistic crime, where Renato Seabra bludgeoned, choked, and mutilated his victim before murdering him.”

Vance further added:

“But the jury’s verdict now, finally, holds Seabra accountable. It is particularly tragic that Carlos Castro was not only … betrayed by his spurned lover, but met a very painful and violent end far from his home.”

In January 2011 Castro was found brutally murdered in his hotel room, bludgeoned to death and then castrated.

The Portugese model murder (also known as the “boy toy trial’) as it was dubbed occurred because De Castro allegedly broke up with Renato Seabra.

After the murder Seabra took $1,600 from his former lover and hung a “Do Not Disturb” sign on the door.

Seabra was caught after he ran into a friend of Castro’s in the lobby, that friend later testified that Seabra said Castro “won’t be leaving the room.”

On January 7, 2011 Carlos Castro was discovered by a hotel worker. The cause of death was ruled as blunt injuries to the head and neck compression.

The two men arrived in the United States together in 2010.

The Portugese model murder case will draw to a close on December 21, 2012 when Renato Seabra is officially sentenced for his grizzly murder of his former lover.

ADHD and Marriage--Are They Compatible?

People suffering from attention deficit hyperactivity disorder represent a rapidly growing slice of the American population, and this has far-reaching implications for society as a whole.

Individuals married to a person with undiagnosed ADHD may contend with severe communication problems, according to psychiatrist Dr. Jennie Byrne, and often those problems can’t be resolved alone.

Byrne discussed her personal experiences and insights during a November 5 interview with Anna Riley of Rosen Law Firm, sharing tips on how couples can learn to live with an ADHD diagnosis. Riley, who works with Charlotte divorce lawyers, uncovered the mystery and myths surrounding the disorder.

“The spouse that has ADHD—they may do things related to being distracted while they’re talking to the other person. For example, they might seem like they’re not really listening… their mind might be going elsewhere,” says Byrne.

Often people who suffer from ADHD have issues remembering little details and managing time, according to Byrne, which can create several small conflicts within a marriage.

“Over time, [small conflicts] can really build up into large conflicts and serious problems in the relationship,” says Byrne. “It’s very common that ADHD in adults goes undiagnosed or misdiagnosed… we’re still learning a lot about ADHD; we didn’t even used to think that it happened in adults.”

Byrne also suggests that the impulsivity and distractability issues of ADHD can cause issues within a marriage. Receiving an accurate ADHD diagnosis for the spouse who’s suffering can improve the chances that a marriage will be successful and may lower the likelihood of divorce.

StayHappilyMarried.com hosts weekly podcasts that feature local and national professionals who provide insider tips on common (and not-so-common) marital issues. Recent episodes include “1,000 Places to Fight before You Die” and “Couples Who ‘Click’: What Makes a Successful Marriage?”

About Rosen Law Firm

Rosen Law Firm has offices in Charlotte, Raleigh and Chapel Hill. Using cutting-edge technology to connect with clients and manage cases, the divorce lawyers at Rosen Law Firm represent people from all over the state. The firm provides help with custody disputes, property distribution, separation agreements, alimony and domestic violence relief.

9 Little Lies You Should Never Tell Your Husband

"These jeans were only $30!" "No, I don't care that your feet are on the coffee table." White lies don't doom a marriage, right? "We don't want to upset, annoy or scare our spouse, so it's easier to lie," says biological anthropologist Helen Fisher, PhD, Chief Scientific Officer of Chemistry.com and Match.com. But fibbing is a slippery slope. "When you lie continually, you won't be able to keep your lies straight. Your husband will find out you're lying, and then there's no trust." And a marriage like that isn't one you want to be in. Here, experts explain common lies women tell, how they can harm the relationship and what you can do instead of stretching the truth. Photo by Thinkstock.

1. "I never talk about our personal life with my friends."
Some women tell their girlfriends about relationship problems, knowing their guys would be upset if they found out. "It's important for spouses to feel like their marriage is a secret, sacred space," says licensed marriage and family therapist Carin Goldstein, creator of Be the Smart Wife. Taking private information to a friend means you're running from a problem to avoid confrontation.

Venting about your husband's messy closet is one thing, but don't take serious issues public. "If you're constantly asking a friend how to solve a problem in your marriage, then you're going to the wrong source," says Goldstein. "You're stunting your relationship by trying to fix the issue with another person."

2. "I had only one glass of wine at dinner."
Your husband may have told you he doesn't like how you act when you drink too much. "Maybe you flirt with other men or yell, which makes your husband critical of you," explains Andra Brosh, PhD. So now you hide how many glasses of wine you've had so he's not on the lookout for bad behavior.

The problem grows when you start layering lies. "You might stop telling your partner where you're going out or make up stories about why you drank, which erodes trust even more." Instead of covering up your drinking habits, address your husband's concerns and work on solutions for valid issues together.

3. "I've never seen Jim outside of work."
If you think your husband can't handle your friendship with another man, you may think telling him about your relationship would create tension. "Partners lie about meeting up with friends of the opposite sex because they believe they won't get caught-and they'd prefer not to open a can of worms," says Dr. Brosh.

But if you say you don't see a male friend and then do, innocent interactions can feel like betrayal if your husband finds out. "Tell your spouse you don't want to jeopardize your marriage for a friendship with your coworker, but you'd like to understand what bothers him about the relationship," says Dr. Brosh. "Work on what's triggering the jealousy. When two people feel a sense of safety in the relationship, having an opposite-sex friendship becomes less of an issue."

4. "I always watch what I eat."
"I buy these amazing coffee cakes sometimes on my way to work," says Renee* from Dearborn, MI. "I think I'll have just a piece at lunch, but end up eating half the cake. I don't want my husband to know I've had that much."

Although some men may care about their wives' munches, the pressure to eat well is usually internal. "Women often make presumptions about their partners without ever hearing them say anything judgmental," says Dr. Brosh. "You're judging yourself and then blaming him for preventing you from owning up to it." Cut yourself some slack about the occasional food indulgence. Tell your husband, and laugh about it with him. Lying about a non-issue only corrodes trust in your marriage.

5. "I wasn't with Katie; I was only with Jennifer and Susan."
If one of your friends continually butts heads with your husband, you may feel like spending time with her means aligning with her. "So she'll tell him she went to lunch with someone else," says Dr. Fisher.

"No one wants to defend her choice of friends," says Dr. Brosh. "But you may resent your partner for 'making you lie.'" The solution: Have a conversation with your spouse about Katie's role in your life. Your husband may better understand the importance of your friendship-and like her a little better too.

6. "These new shoes? They were on sale."
"I bought electronic toothbrushes from my dentist," says Anna* from Fairfield, CT. "They were $70 a piece and I said they were $50 a piece. I know my husband would've said our regular toothbrushes were fine if the price was too high." Dr. Brosh says lies about purchases stem from the "power differential in the relationship, often modeled by parents growing up. The man controls the money, and the wife thinks she needs permission to purchase something."

Agree to discuss buys over a certain amount with each other, and feel free to keep mum when the total is under that (knowing that he'll do the same). If your husband asks about a particular item, tell the truth. Past generations of men may have held the purse strings, but that doesn't mean your hubby does or wants to; he may just be curious.

7. "I didn't forget to go to the bank. I got busy and figured I'd go later."
You may not realize you tell the tiniest lies, but it probably comes from a sense you have to give a more legitimate excuse than the real reason, like simply spacing out. "Lying about little things is an avoidance of feeling shame," says Dr. Brosh.

Small fibs signify a deeper issue of insecurity. "If your partner tends to be condescending, lying might be a direct response to that," explains Dr. Brosh. If you notice a pattern of senseless lies, be upfront with your husband so he can have a broader view of the situation and help you work through it.

8. "Of course you're great in bed. I'm totally satisfied."
Whether it's singing his praises or faking an orgasm, lying about between-the-sheets fulfillment happens a lot. "Wives don't want to feel responsible for their husband's shame," says Goldstein.

Dealing with dissatisfaction this way actually deepens the issue. "If a need's not being met, the problem will get bigger," says Goldstein. So nip it in the bud. "First, ask yourself why you can't orgasm. Figure out what works for your body, and then say, 'I love it when you do this. Let's keep doing that.'" Positive reinforcement encourages your husband to continue doing the things you like in bed, which ultimately satisfies you both. Bonus: You build his confidence and spare his feelings.

9. "No, that doesn't bother me at all."
The honeymoon phase causes newlyweds to insist things that really bug them don't-and the annoyance can persist for years. If you're afraid of rocking the boat, you may hold grievances in until you're bubbling with anger. "Spouses blow off little things, avoiding having to talk about feelings and resolve issues," says Goldstein. "But it's a major issue. I just dealt with this in practice and it ended in divorce."

A little recurring thing is a big deal. "With Twitter, Facebook and social media, there's so much room to act out what isn't getting resolved in marriage, confiding in another person," says Goldstein. Avoid that and be honest with your spouse. Try: "This may sound silly, but it annoys me when you put your feet on the coffee table. You leave smudges. Could you please use the footstool?" It may take some time (and reminders) to tweak his habit, but he'll get there-without you holding a grudge against him.

*Names have been changed

Fasting may not be necessary before cholesterol test

Before taking a cholesterol test, adults are typically told to fast for up to 12 hours or else levels in the bloodstream may be skewed by the recent meal. A new study, however, finds fasting may not be necessary after all.

The study, published Nov. 12 in the Archives of Internal Medicine, found the amount of time a person spent fasting prior to a cholesterol test had little impact on the end results.

"This finding suggests that fasting for routine lipid level determinations is largely unnecessary," wrote the authors.

A cholesterol test, also called a lipid panel or lipid profile, measures the four types of lipids (fats) found in the blood, according to The Mayo Clinic. It measures low-density lipoprotein (LDL) cholesterol, sometimes called "bad cholesterol" because high levels of it could lead to plaque buildup in the arteries, potentially causing a heart attack and stroke.

The test also measures high-density lipoprotein (HDL) cholesterol, sometimes called "good cholesterol" because it helps carry LDL away from the blood. Cholesterol tests also measure total cholesterol and triglycerides, a type of fat found in the blood. People are typically told to have no food or liquids other than water for nine to 12 hours before the exam.

Researchers at the University of Calgary in Alberta, Canada, examined laboratory data on cholesterol tests taken over a 6-month period in 2011 of over 209,000 participants (111,000 of which were women).

Participants had fasting times that ranged from less than one hour to 16 hours, and when the researchers crunched the data, they found minimal differences between patients' cholesterol screening results. On average, there was less than a 2 percent difference for total cholesterol and HDL cholesterol, less than a 10 percent difference for LDL cholesterol and less than a 20 percent difference for triglyceride levels -- regardless of fasting times.

Study author Dr. Christopher Naugler, assistant professor of clinical pathology at the University of Calgary, in Canada, told HealthDay that some patients, such as those with high triglyceride levels, may still require repeat fasting cholesterol tests. But for many others, the fasting test is largely unnecessary.

"Eliminating fasting as a general requirement for cholesterol testing could greatly increase convenience for patients without significantly altering test results," he said.

In an accompanying editorial published in the same journal, Dr. J. Michael Gaziano, a chronic disease epidemiologist at Harvard Medical School in Boston, said the "exceedingly small" gain of information from a fasting blood test likely does not offset the logistical constraints put on patients, laboratories and doctors for the procedure.

"This, in my opinion, tips the balance toward relying on nonfasting lipid profiles as the preferred practice," he wrote.

What Supermodel Adriana Lima Eats To Get Ready For The Victoria's Secret Fashion Show

Supermodel Adriana Lima just had a baby. Even so, she'll definitely be ready to walk in this year's Victoria's Secret Fashion Show.

While other models, like Gisele Bundchen, claim to eat steak and pizza, Lima is actually honest about her pre-show regiment.

Last year, she told the Telegraph exactly how she gets ready:

"She sees a nutritionist, who has measured her body's muscle mass, fat ratio and levels of water retention. He prescribes protein shakes, vitamins and supplements to keep Lima's energy levels up during this training period. Lima drinks a gallon of water a day. For nine days before the show, she will drink only protein shakes - "no solids". The concoctions include powdered egg. Two days before the show, she will abstain from the daily gallon of water, and "just drink normally". Then, 12 hours before the show, she will stop drinking entirely."

In addition to her liquid diet, Lima works out for two or more hours a day.

Other models are also consuming liquids before the show. Fellow Angel Doutzen Kroes tweeted her smoothie recipe, which included cocoa, chia seeds, acai berries and flaxseed.

The fashion show is tonight but won't air until next month. We'll be there to show you what happens.

The Victoria's Secret Fashion Show 2012

The 69th Regiment Armory at the Lexington Avenue in New York City became the world’s headquarters of global beauties on November 7th, during the taping of the annual Victoria’s Secret Fashion Show.

Against all weather obstacles, the sequels of hurricane Sandy and a snow storm, some of the world’s most recognized top models took the spotlight during the annual lingerie event, which is now the most watched event of its kind in the world.

Two shows were scheduled for thisw year, the first at 4 pm and the second one at 8 pm. The press had the opportunity to share with the VS Angels during a special photo-op at 1 pm which included them getting ready with hair and make-up.

The show, which lasted a little over an hour in both instances, included performances by Rihanna, Bruno Mars and Justin Bieber. Six concepts were designed for this year, which were Circus, Calendar Girls, Dangerous Liaisons, Pink is Me, Silver Screen Goddesses and Bloom.

Mars performed his single ‘Locked out of Heaven’ during Calendar Girls, while Rihanna performed ‘Diamonds’ during Dangerous Liaisons. Bieber sang his hit ‘Beauty and the Beat’ during Pink is me, the VS line aimed at high school and college students.

There were 37 models (originally 38) after the withdrawal of Brazilian Lais Ribeiro who hurt her ankle during rehearsal and was unable to walk during the show. These lucky ladies walked the world’s most coveted runway this year:

- Adriana Lima (Brazil)
- Alessandra Ambrosio (Brazil)
- Behati Prinsloo (Namibia)
- Candice Swanepoel (South Africa)
- Doutzen Kroes (Netherlands)
- Erin Heatherton (USA)
- Lily Aldridge (USA)
- Lindsay Ellingson (USA)
- Miranda Kerr (Australia)
- Barbara Fialho (Brazil)
- Barbara Palvin (Hungary)
- Bregje Heinen (Netherlands)
- Cameron Russell (USA)
- Cara Delevingne (UK)
- Constance Jablonski (France)
- Dorothea Barth Jorgensen (Sweden)
- Elsa Hosk (Sweden)
- Frida Gustavsson (Sweden)
- Hilary Rhoda (USA)
- Ieva Laguna (Latvia)
- Isabeli Fontana (Brazil)
- Izabel Goulart (Brazil)
- Jacquelyn Jablonski (USA)
- Jasmine Tookes (USA)
- Jessica Hart (Australia)
- Joan Smalls (Puerto Rico)
- Jourdan Dunn (UK)
- Karlie Kloss (USA)
- Lily Donaldson (UK)
- Liu Wen (China)
- Magdalena Frackowiak (Poland)
- Maud Welzen (Netherlands)
- Shanina Shaik (Australia)
- Sharam Diniz (Portugal)
- Shu Pei (China)
- Sui He (China)
- Toni Garrn (Germany)

The 17th annual Victoria’s Secret Fashion Show will be televised on Tuesday, December 4th on CBS.

Amgen’s Drug Lowers Cholesterol Among Statin Intolerant

Amgen Inc. (AMGN), the world’s largest biotechnology company, said its experimental heart drug lowered cholesterol levels in patients unable to take standard medicines such as Pfizer Inc.’s Lipitor because of side effects.

The drug, AMG-145, which targets cholesterol-regulating gene PCSK9 in the liver, reduced LDL, or bad cholesterol, 51 percent in patients intolerant to medicines like Lipitor, called statins, after 12 weeks, and 63 percent among those taking it in combination with Merck & Co.’s (MRK) cholesterol treatment Zetia, according to a study presented today at the American Heart Association meeting in Los Angeles.

Amgen is focusing on the drug’s potential to help offset declining sales of its anemia drugs Aranesp and Epogen, which together will generate $4 billion in estimated sales this year and face increased competition by 2015. The Thousand Oaks, California-based company is competing with some of the world’s biggest drugmakers, such as Pfizer, Roche Holding AG (ROG) and Sanofi (SAN), to be first to market with the new cholesterol medicine.

“Close to a million people in the U.S. alone who are treated with statins cannot tolerate them or the doses needed for effective cholesterol control,” said Evan Stein, director of the Metabolic and Atherosclerosis Research Center in Cincinnati and one of the study’s researchers.

The market for these PCSK9 inhibitors may be at least $10 billion, Adnan Butt, an analyst with RBC Capital Markets in San Francisco, said in an e-mail last week. In the U.S. about 1 million can’t take statins because of side effects such as muscle soreness, he said.
Highest Dose

Pfizer (PFE) today also released data on its PCSK9 inhibitor, RN 316, showing the drug at its highest dose lowered bad cholesterol in patients on statins by 80 percent after their first treatment. Cholesterol fell so low for some in the 135- person study, they weren’t eligible to get a second dose, said Barry Gumbiner, lead researcher on the medicine for New York- based Pfizer, the world’s largest drugmaker.

At the end of the 12-week study, those getting the highest dose had a decline in LDL of 56 percent. Pfizer didn’t see any unusual safety signals, Gumbiner said.

In a separate clinical trial, Amgen said its drug reduced LDL as much as 56 percent in patients with a genetic disorder called heterozygous familial hypercholesterolemia, some of whom were also taking statins and Zetia. HeFH, which affects at least 1 in 500 people worldwide, elevates LDL as well as total cholesterol and leads to early cardiovascular disease and death, the company said in a statement.

Amgen is scheduled tomorrow to release data at the heart meeting on how patients who are unable to reach appropriate levels of cholesterol on statins responded to AMG-145.
Under Skin

Shares of Amgen declined less than 1 percent to $86.35 at the close of trading in New York. The stock has increased 34 percent this year. Pfizer gained less than 1 percent to $24.58.

Pfizer has started another study involving 350 patients getting an injection under the skin rather than an infusion. The company expects results in June. Pfizer’s drug was developed by Scientists at Rinat Neuroscience, which Pfizer acquired in 2006.

Fashion week is back with a stylish flourish

THE fourth annual Oxford Fashion Week starts today with a range of events across the city.

Oxford Fashion Week will run until Saturday, showcasing up-and-coming designers at themed fashion shows.

Carl Anglim, 26, started Oxford Fashion Week in 2009 with his partner Victoria Watson, and they have run it every year since, until now. This year, they have taken a back seat.

Mr Anglim said: “We created a production team, BMLY (Big Me Little You), and they have been responsible for producing it.

“I am really excited to see how they have put the week together, and for the first time to be a guest at something we helped to create.”

Oxford’s previous three fashion weeks featured the work of such big name designers as Alexander McQueen, Matthew Williamson and Valentin Yudashkin.

Events for this years begin tonight at Oxford’s oldest independent cinema, the Ultimate Picture Palace.

The venue will host an invite-only black tie event, showing a special screening of the 2009 film Coco before Chanel, starring Audrey Tautou.

OFW’s official launch party will kick off on Tuesday night at the Living Room in Oxford’s Castle Quarter.

But it’s not all black-tie and VIP as city-shoppers will have the opportunity to experience a free cat-walk show at the Claredon Shopping Centre on Wednesday.

One of the new events for this year will be a free, ethical fashion fair at Oxford Town Hall on Thursday.

The fair will feature talks from experts in the subject, stalls and ethical fashion workshops, making it more interactive than a catwalk show. It takes place between noon and 5pm.

Also on Thursday is the cosmopolitan show, at the Town Hall, between 8pm and 10.30pm, which is a showcase for independent designers to demonstrate their wares, particularly focusing on pret a porter (ready to wear) and lingerie.

Friday sees the elysium concept show, for avant garde fashion, between 8.30pm and 11.30pm at the town hall.

The main event is the black tie haute couture show at the Ashmolean Museum on Saturday. There will be a red carpet reception, with celebrities, the national press and fashion buyers in attendance.

European fashion buyers look to Nigeria

A model struts the runway wearing a flowing newspaper print gown in this African megacity where international high-end fashion buyers are looking beyond the country's bleak headlines to uncover the next new thing.

There have been steady efforts to turn Lagos, a city with a fearsome reputation, into a fashion destination. They reached new heights at the MTN Lagos Fashion & Design Week that ran from Oct. 24 to 27 and drew European high-fashion brands such as the United Kingdom's Selfridges & Co. and Munich-based MyTheresa.com to Nigeria for the first time.

Ituen Basi's newspaper inspired Spring/Summer 2013 collection was among 39 collections spotlighted at the city's latest major fashion week. The Nigerian label's collection evoked fun and glamour through its use of print and color — characteristics which have come to define the vibrant local fashion scene.

With local brands seeking wider platforms and international retailers hungry for novelty, designers and buyers see opportunities for collaboration.

"There's something about the fresh, the unknown, the possibility of seeing a new brand springing forth into the limelight. ... These are becoming interesting to people outside Nigeria," said Omoyemi Akerele, the fashion week's founder and creative director.

An encouraging response to African-inspired designs by top Western labels gives buyers confidence that designs straight from the continent will also sell.

"Over the past few seasons, there's been a strong trend for print," said Bruno Barba, the brand public relations manager at Selfridges. "If you look at the collection of Burberry inspired by Africa last year; there was also Vivienne Westwood, Paul Smith. ... They've made that inspiration quite mainstream now. So, for us, it was interesting to take that trend and take it from its roots in Africa."

Online retailer MyTheresa.com, which ships top designers' clothes including Miu Miu, Givenchy, Lanvin and Isabel Meron to clients in 120 different countries, is also looking for products in Nigeria that will sell well. The company hopes that will set it apart from the competition in a fast-paced industry.

"For me, Nigeria represents a fun individualism," the company's buying director Justin O'Shea said. He also said that MyTheresa.com was looking to work closely with designers and adapt products for their clientele if needed.

Previously, several Nigerian designers have helped put the West African nation on the global fashion map.

Deola Sagoe has gained recognition from U.S. Vogue editor Andre Leon Talley and Oprah Winfrey. London-based Duro Olowu is considered one of Michelle Obama's favorite designers. Maki Oh has dressed American singer Solange Knowles and Hollywood actress Leelee Sobieski from her Lagos workshop. Jewel By Lisa, who has also dressed celebrities, designed limited edition BlackBerry mobile phone skins and jeweled cases for Canadian manufacturer Research In Motion Ltd.

While looking to Nigeria could bring much-needed novelty to clothes targeted to global audiences, it could also endear a Nigerian clientele. Though the majority of the nation lives on less than $2 a day, the nation's wealthy elite have a growing appetite for top-shelf brands. Luxury goods stores are increasingly opening in a country where seemingly gratuitous displays of wealth are the norm.

"Nigerians are part of our Top 10 highest-spending foreign customers," Barba said. "It felt right for us to try and find a response that would appeal to them, excite them and be over and above what they already buy, almost as a recognition that they're an important part of our consumer base."

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JEWEL BY LISA

Fashion week after fashion week, Lisa Folawiyo, the creative director of Jewel By Lisa, is a consistent Nigerian designer. She recently started retailing at the New York-based online luxury store Moda Operandi and continues to draw attention from international buyers and labels looking for a modern interpretation of African style.

Her Spring/Summer 2013 collection is named "Fula" after the Fulani women it draws inspiration from. The Fulani are a nomadic people spread across several African countries, including Nigeria.

Their women typically have fine traits and slender frames, not unlike the models that took to the catwalk with soundtrack that crossed the high-pitched melody of the African guitar and the heavy bass of house music.

The Jewel by Lisa collection turned traditional loop earrings into a motif that repeated itself throughout her satin fabrics across stunning color combinations.

ANITA QUANSAH LONDON

Anita Quansah London is a prolific one-woman operation based in a London workshop. The Ghanaian-Nigerian designer describes her work as a "labor of love." She sells to a global market including Asians and Europeans. She says she is now in talks to build a diffusion line to meet up with the growing demand of her work that has caught the eye of such designers as Christian Delacroix.

Her Spring/Summer 2013 collection is dramatic for "ladies who want to make a statement when they walk in to a room."

Her show-stopping bib necklaces are embellished with intricate bead work. The beads include imitation coral beads used for traditional outfits in southern Nigeria. Some bibs are lined with chicken feathers which also evoke traditional heirlooms.

Her dresses were understated and mostly in solid black, ceding the limelight to the jewelry that included suggestive chain designs inspired by bondage. Quansah said she wanted to show "women that weren't afraid to be sexy."

LANRE DASILVA AJAYI

Designer Lanre DaSilva Ajayi is well-known in Nigeria's fashion scene for her love of 40s elegance. International buyers such as Selfridges & Co. expressed interest in her designs for retail at their UK stores.

Her ultra-feminine collection used a color palette ranging from cool nude and turquoise to warm orange and gold.

She showed flowing silhouettes and easy-to-wear maxi dresses, using chiffon, raw silk lace and the lace used in traditional Nigerian outfits to carve European shapes.

Her clothes are for the woman on the move, bold and sophisticated.

JOSH SAMUELS

The MTN Lagos Fashion and Design Week 2013 was also the culmination of a months-long competition for new talent. The competition winner was menswear designer Josh Samuels, an architect turned designer that offered a geometric collection.

"I like things organized and appropriate," said Samuels who won the equivalent of $25,000 and the opportunity to be stocked in some Nigerian boutiques.

His collection called "Casanova" included finely tailored suits with classic checkered and houndstooth patterns and matching string ties.

Flu vaccine may protect against heart disease

Getting a flu shot this season may not only greatly lower your risk of influenza this year, it may also lower your risk of heart disease, a new review from Canada suggests.

Results show that people who received the flu vaccine were 50 percent less likely to experience a heart attack or stroke, and 40 percent less likely to die from one, compared with people in the unvaccinated control group.

The flu vaccine could be an important way to maintain heart health and ward off strokes and heart attacks, the researchers said. They presented their findings at a cardiovascular disease research meeting Monday in Toronto.

In the study, Dr. Jacob Udell, a cardiologist at Women's College Hospital and the University of Toronto, and colleagues looked at four previous studies involving a total of more than 3,000 people whose average age was 60 — some with previous heart disease, and some without such conditions. Participants in all the studies were randomly assigned to receive a flu vaccine, no vaccine or a placebo injection, and were tracked for the following year.

The findings suggest that “perhaps that the flu vaccine is a heart vaccine,” Udell said.

During the year after vaccination, there were 187 cases of heart attacks or stokes, including 65 deaths.

Regardless of whether study participants had a history of heart disease, those who got the flu vaccine were less likely to have cardiovascular events, or die them from.

While the reason for the link is not exactly clear, Udell said it may be that when people develop heart disease, some factor "tips them over the edge," such as plaque clogging arteries, or lower levels of oxygen as a result of the flu.

The flu vaccine may stop this "tipping" by preventing flu, or by actually breaking up plaque in the arteries. “Either one is very provocative, and it's important to drill down and get the answer,” Udell said.

Dr. Sarah Samaan, a cardiologist and director of the Women’s Cardiovascular Institute at Baylor Heart Hospital in Plano, Texas, said the key to the link may be in reducing inflammation.

When someone gets the flu, blood levels of inflammatory substances rise, and inflammation of the blood vessels can trigger heart attacks.

“This happens because inflammation can make cholesterol plaques in the blood vessels unstable," Samaan explained. Unstable plaques are more likely to develop tiny cracks, which can cause blood clots to form. Such clots can block blood flow within arteries, causing a heart attack (if the blood vessel supplies the heart) or a stroke (if the artery feeds the brain), she said.

Udell cautioned that the 50 percent reduction in cardiovascular events seen in the study may be a high number, but said that even if the flu vaccine reduced the risk of a heart attack or stroke by just 10 percent, vaccination could make a major dent in saving lives.

A larger study could help firm up the numbers, he said, and he hopes to start one.

Isis Shares Fall 22% On Concerns About Drug

Shares of Isis Pharmaceuticals plunged 22 percent Tuesday, after a U.S. Food and Drug Administration committee released a report expressing serious safety concerns about its experimental cholesterol drug, Kynamro.

The drop erased $280 million from Isis’ market value. At the end of the trading day, Isis’ stock value had tumbled to $1.03 billion.

The FDA report said that taking Kynamro is associated with increased liver fat deposits, a risk factor for cirrhosis and death. However, the report also said the drug is potentially beneficial to its intended patient population. Those people have a disease that causes extremely high blood levels of LDL, or “bad” cholesterol. Those with the disease, homozygous familial hypercholesterolemia, have a greatly increased incidence of cardiovascular disease.

Meanwhile, shares of competitor Aegerion Pharmaceuticals rose 10 percent. On Monday, the same FDA committee released its report on a similar drug from Aegerion, called lomitapide.

The FDA’s Endocrinologic and Metabolic Drugs Advisory Committee is scheduled to review lomitapide today. On Thursday, the committee will review Kynamro.

Kynamro is the flagship drug for Carlsbad-based Isis. It was developed with Isis’ gene-blocking “antisense” technology. Generically known as mipomersen, the drug reduces blood levels of LDL. It could provide Isis entry into the multibillion-dollar market for cholesterol-fighting drugs.

Isis and its Paris-based marketing partner, Sanofi, aim to get approval first for the hypercholesterolemia drug in the homozygous form, then for a milder form. Later, the companies plan to seek approval for patients who don’t have the disease, but are also at high risk of cardiovascular illness. About 1 million Americans fit that category, Isis says.

The safety concerns described in the report could limit Kynamro’s use, said Damien Conover, an analyst with the Chicago-based research firm Morningstar.

The report may not stop the FDA from approving Kynamro for familial hypercholesterolemia, Conover said. Those patients have few other options. However, the findings make it less likely that Kynamro will be eventually approved for larger populations, Conover said.

The FDA is scheduled to decide on Kynamro by Jan. 29.

3 Great Outfit Ideas to Steal From Paris Fashion Week - Street Style Edition


(ImaxTree)

Paris Fashion Week just wrapped up, and while there were plenty of amazing looks on the ready-to-wear runway, there were also so many incredible street style looks chock-full of fashion inspiration.

Here's how to get three Paris Fashion Week street style looks for your very own fall wardrobe.

Dressed-up prep:


(ImaxTree)

If you ever thought that raggedy old college sweatshirt could only be worn over pajamas or at the gym, think again! Take any bright collegiate pullover, and wear it with a crisp denim button-up, skinny jeans, and strappy heels for an adorable academic fall look.

To get a similar style, try Free People's Vintage Yellow Pullover Sweatshirt ($168) or Recycled Karma's College Sweatshirt ($59). Of course you can also throw on one of your very own university raglans hidden in the back of your closet!



As for the rest of the layers, go for a lighter wash denim shirt, like this Wrangler button-up ($149.51) and darker wash skinny jeans, like this Ann Taylor Loft pair ($59.50). Don't forget the strappy stillettos and zipper pouch clutch for the finishing touches!



A bright cape:


(ImaxTree)

If you're tired of wearing your ol' gray wool pea coat, pop on a bright red cape for a statement-making piece of fall outerwear.



For a similar style, try Cole Haan's belted cape coat ($595). Leave the rest of your look sleek and minimal—a crisp white button-up, black skinny jeans, and little black booties with a deep cut in the front, like this DKNY pair ($270) should do the trick!

Light layered prints:


(ImaxTree)

This street style star proves that you don't have to ditch your white and light-hued pieces when fall fashion hits. Layering is key when it comes to incorporating your favorite spring and summer items into your autumn wardrobe.




To get this look wear a white brocade or white jacquard tee over a light printed blouse, like this Equipment silk chiffon shirt ($200). To make the light colors standout, fasten a floral statement necklace underneath your collar, like this BaubleBar Blue Daisy necklace ($84) and wear an oversized zipper pouch or clutch, like this ASOS floral clutch ($56.29).


What do you think of these street style looks from Paris Fashion Week? Would you want to recreate them for yourself?

What Do You Think of Amanda Seyfried's Matchy-Matchy Style?

It's nothing new to match one's lipstick to one's dress, but while the general rule of thumb is to keep the rest of your ensemble relatively subdued, Amanda Seyfried was all about breaking the rules. At the Miu Miu show earlier today during Paris fashion week, the actress coupled a bold purple lipstick with an equally intense pair of purple Prada Mary Janes. Instead of going with a more staid outfit choice, however, Amanda livened things up with a bright red pantsuit. There's never a better time to experiment with daring colour choices than at a fashion show, but is Amanda's coordinating palette more of a clash than a smash?

Fashion Show Benefits Rockingham Memorial Hospital

A fashion show hopes to show more than just clothes.

The Benefit Breast Cancer Survivor Fashion show hosted by Casual Friday Boutique is trying to raise awareness and save more lives.

Most of the models walking down the runway are breast cancer survivors.

At the event, they're hoping that their story gives hopes to others battling the disease.

They're also trying to promote self-examination and mammograms.

All proceeds from the event will go toward mammogram machines at the Rockingham Memorial Hospital.

The models said it's encouraging for people to see there are survivors.

Angie Williams said it's important to show those who are battling with the disease that there is hope.

"When they see that you can still be joyful, you can still live a full life and you don't have to be afraid. I don't live day by day thinking i have another diagnosis of breast cancer, that's no way to live," she said.

Rita Purkey said she does anything that helps raise awareness about breast cancer.

" [I'm] proud to do it and thankful that I'm here to be able to do it."

WHSV-TV3 News anchor Alyson Bruner was also there, supporting the cause by modeling some clothes.

Diabetes center offers expanded services

Recent upgrades at the Northeast Center for Diabetes Care and Education will provide a more comprehensive and financially supported service for patients across the region.

Dr. Jonathan Beach, who has managed his own Type 1 diabetes since his childhood, oversees activity at the Northeast Center, which shares office space with Urgicare of the Northeast at Hammond Lane.

“We’ve put together a program to meet the complete needs of diabetic folks in the North Country,” Beach said as he talked about some of those upgrades recently. “We offer diabetes-management programs, insulin management and other education programs.

“As always, we encourage regular exercise along with appropriate diet,” he added. “We’ve recently brought in a registered dietitian to ensure that service is available to our patients.”

Tracey Soulia is the new dietitian who will be available to assist patients with diabetes in managing their weight and making proper food choices.

“Every patient is different, but we can look at the medical diagnosis (of each patient) and help patients manage their diets so they are making healthy food choices without side-effects,” Soulia said.

The proper diet for a diabetic does not necessarily focus on calories; the patient has to be conscious of carbohydrates, minerals and other nutrients in food that can impact blood-sugar levels, she explained.

“The body breaks carbs down to different types of sugars,” she said, adding that the body also uses insulin to pull those sugars into cells, a process that is impacted by diabetes.

The focus on carbohydrates is complicated by the fact that all types of food contain carbs, including normally healthy choices like fruit.

Blood pressure can also play a role in the diabetics diet: reducing salt in the diet is one measure to help reduce an elevated blood pressure.

“Each patient needs individual support, Soulia said. “We always encourage activity, but there are other factors we always have to consider.”

The center is also working on a plan to provide educational visits to grocery stores to help patients choose the most appropriate foods for their personal needs, Beach noted.

“It’s one thing to talk about healthy choices, but it’s another matter when you can actually see what’s available (at the grocery store),” he said.

The Northeast Center for Diabetes has also hired a new office manager, Andrew Lushia, who has provided some innovative suggestions for daily operations of the center.

For instance, he recognized an opportunity to move medical technician Sue Dumar into a more permanent position to assist patients with their insurance needs.

“Sue is very good at getting what we need from insurance companies,” Beach said. “She will go out of her way to make sure the patient receives whatever support is available (through insurance).”

That focus has not only proven beneficial for the patients but has also allowed the practice to provide more cost-effective supplies, such as blood-meter strips that patients use to analyze their blood-sugar levels.

“The amount of confusion connected to insurance companies is unbelievable,” Beach said. “Sue has a wonderful way of simplifying information. She is very good at keeping track with trends.”

Beach also continues to work with a company that trains dogs to recognize blood-sugar levels. He has purchased a dog that stays with him 24 hours a day and is working with about six patients who are also interested in the innovative technique.

He also works closely with several pharmaceutical companies in providing educational services across the region and beyond.

The center first opened in 2007 and provides individualized care for diabetics.

According to the National Diabetes Education Program, more than 20 million Americans have diabetes, including an estimated 6.2 million people who are undiagnosed. More than 4,000 new cases are identified every 24 hours.

Stem Cell Transplants May Show Promise for MS

New research suggests that stem cell transplants to treat certain brain and nervous system diseases such as multiple sclerosis may be moving closer to reality.

One study found that experimental stem cell transplants are safe and possibly effective in children with a rare genetic brain disease. Another study in mice showed that these cells are capable of transforming into, and functioning as, the healthy cell type. The stem cells used in the two studies were developed by study sponsor StemCells, Inc.

Both papers appear online in Science Translational Research.

The work, while still in its infancy, may have far-reaching implications for the treatment of many more common diseases that affect the brain and nervous system.

Researchers out of the University of California, San Francisco (UCSF), looked at the how neural stem cells behaved when transplanted into the brains of four young children with an early-onset, fatal form of Pelizaeus-Merzbacher disease (PMD).

Can Stem Cell Transplants Help Treat MS?

PMD is a very rare genetic disorder in which brain cells called oligodendrocytes can’t make myelin. Myelin is a fatty substance that insulates the nerve fibers of the brain, spinal cord, and optic nerves (central nervous system), and is essential for transmission of nerve signals so that the nervous system can function properly.

In multiple sclerosis, the myelin surrounding the nerve is targeted and damaged by the body’s immune system.

The new study found that the neural stem cell transplants were safe. What’s more, brain scans showed that the implanted cells seem to be doing what is expected of them -- i.e. making myelin.

Researchers compared treated areas of participants' brains with untreated areas. "The study goes beyond safety and we see some effects in the transplanted region that are consistent with the appearance of myelin, at one year,” says study author David H. Rowitch, MD, PhD. “It is not definitive, but it is suggestive.” He is a professor of pediatrics and neurological surgery at UCSF, and is the chief of neonatology at UCSF Benioff Children’s Hospital.

PMD is rare, but other diseases that affect the myelin, such as MS, are more common.

So is it possible that these same stem cell transplants could also benefit these other diseases? Although the possibility exists, Rowitch is noncommittal at this point. “We don’t have data that this could work in MS or other diseases,” he says.

With PMD, the cells that produce myelin are not doing their job. Other diseases involve multiple causes or pathways. If further research in treating PMD pans out, the next step will be to look at MS and other diseases that affect myelin, Rowitch says.

Nancy L. Sicotte, MD, is the director of the Multiple Sclerosis Program at Cedars-Sinai Medical Center in Los Angeles. She says that MS may be more complicated to treat with stem cell therapy.

“With MS, we would be trying to introduce stem cells into an inflamed nervous system,” she says. "To be effective, we have to stop the inflammation process, which we haven’t fully been able to do yet.”

Still, “stem-cell based therapies hold a lot of promise and potential,” Sicotte says. “You always have to temper that with the fact that it takes time to bring a great idea in the lab to humans.”

CINJ studies combo of vaccine and hormone therapy in prostate cancer treatment

Investigators at The Cancer Institute of New Jersey (CINJ) have partnered with the National Cancer Institute (NCI) and launched a clinical trial examining the effectiveness of a combined vaccine and hormone treatment for prostate cancer that is resistant to hormone therapy and not visible on imaging tests such as a CT scan and a bone scan. Researchers will compare these effects to those in patients who are receiving hormone therapy alone. CINJ is a Center of Excellence of the University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School.

According to the NCI, one in six men will be diagnosed with prostate cancer in his lifetime. Numerous studies have shown that while the majority of prostate cancer patients are diagnosed with disease that has not spread beyond the prostate, between 30 and 40 percent of those patients will have disease progression within 10 years after having received initial treatment as shown by a rise in prostate specific antigen (PSA) level. Patients in this instance who have a rising PSA level without evidence of disease spread on imaging tests are commonly treated with hormone therapy. Even with hormonal therapy, PSA levels can still rise.

Investigators at CINJ and the NCI will explore using the body’s own T-cells as a means to directly target prostate cancer.Tcells are a type of white blood cell that plays a key role in the body’s natural defenses in fighting off disease.At focus in this trial is an experimental vaccine called PROSTVAC VF. PROSTVAC VF is a virus that has been modified to produce a PSA protein whose presence helps focus the body’s immune response against the prostate tumor. Other human genetic material in the PROSTVAC VF vaccine produces three proteins that help increase the T-cell’s ability to destroy its target.

All patients accepted for this study will receive flutamide, which is a standard hormone therapy for prostate cancer. Patients will randomly be assigned to receive the vaccine or no vaccine.Those patients not originally assigned to receive the vaccine will be given it at a later date if PSA levels are rising.

Mark Stein, M.D., medical oncologist at CINJ and assistant professor of medicine at UMDNJ-Robert Wood Johnson Medical School, is the lead CINJ researcher on the new study. “With growing use of immune therapy to treat advanced forms of prostate cancer, there is great interest in exploring the impact that this type of treatment could have on the disease at a pre-metastatic stage,” he said.

Adults who are diagnosed with prostate cancer that is unresponsive to hormone therapy and not visible on imaging tests such as a CT scan and a bone scan, and have a rising PSA level, are eligible to take part in the trial, although other criteria must be met. Prior to being accepted into the study, participants would be required to undergo a number of tests including blood work and a physical exam. Participants would undergo PSA testing as well as other assessments on a regular basis throughout the study.

Free contraception may prevent abortions

Contraception includes condoms and birth control pills, but there are other, longer-term methods that are effective and reversible: Intrauterine devices and implants.

A new study in the journal Obstetrics & Gynecology set out to see what would happen if these methods were given out at no cost. The study incorporated more than 9,000 girls and women at risk for unintended pregnancy.

Researchers found that teen births within the group of women who were part of this program was 6.3 per 1,000, which is much lower than the national rate of 34.1 per 1,000.

"We already spend $11 -- 12 billion on unintended pregnancies in the U.S., and I bet that money could go very far to provide contraception for many women in the U.S.," said Dr. Jeffrey Peipert, lead study author and researcher at Washington University in St. Louis School of Medicine.

Peipert and colleagues also found that the percentage of abortions that were repeat abortions was lower in this group of participants than in the St. Louis region in general, and the national average, during 2008 to 2010. The study intervention appeared to prevent one abortion for every 79 to 137 women who participated.

In previous research, Peipert and colleagues showed that these longer-term methods are as much as 20 times more effective than the birth control pill, the hormone patch and the hormonal vaginal ring. The long-acting options do not require the user to remember to take medications or change out a device, failings which can lead to unwanted pregnancies.

There are many barriers to the widespread use of long-acting reversible contraceptives in the United States, he said. One is the cost. One IUD costs a little over $700, not including the insertion fee, Peipert said, but it is very cost-effective given how long these devices last compared to other methods. The implant lasts three years, while the copper IUD lasts 10 years.

These longer-term options should be covered under insurance plans under the Affordable Care Act, although it remains controversial whether religious-based insurance carriers must provide contraception, Peipert said.

Another challenge is that clinicians are wary to give them to very young women, although they have been shown to be safe. Patients are also less aware that these methods exist.

Participants in the program were between 14 and 45 years old, did not want to get pregnant for at least 12 months, and planned to engage in sexual activity with a male partner within the next six months. About 5,000 participants received a free reversible contraceptive method for three years, while the rest got it for two years. Researchers used a variety of methods to enroll people in the study; 16% of the participants had been recruited at abortion facilities.

"Increasing access to the most effective contraceptive methods by removing cost and access as barriers has greatly increased the number of adolescents and women in the St. Louis region using the most effective methods of birth control," the study said.

There are limitations, however. This study was limited to a very specific demographic area, so it's hard to say how it would apply on a broader scale. Also, the study authors did not directly measure unintended pregnancies, but used measures of teen pregnancy and repeat abortions as a proxy.

The funding for the study came from the Susan Thompson Buffett Foundation. One of the study authors, Dr. Tessa Madden, is on the Speaker's Bureau for Bayer Pharmaceuticals; there were no other conflicts of interest reported. The Washington University Human Research Protection Office gave approval before recruitment.

Cancer evidence builds against sunbeds


An international study which adds to growing evidence surrounding the cancer-causing risks of indoor tanning has prompted calls to tax the industry and increase health warnings to consumers.

The research comes as NSW pushes ahead with legislation to ban tanning salons by 2014, while Queensland is considering a similar move.

The study, published in the British Medical Journal this week, found that people who used tanning beds were more likely to develop two types of non-melanoma skin cancer, basal and squamous cell carcinoma.

The findings follow a study in the same journal in July that showed the risk of melanoma from sunbed use was 20 per cent, rising to 87 per cent if people were exposed before the age of 35.

Experts from the Queensland Institute of Medical Research said the two studies provided more convincing evidence that exposure to artificial ultraviolet radiation can cause skin cancers.

Senior researcher Catherine Olsen and Adele Green, the head of the cancer and population studies group at the university, said sunbeds were now banned in Brazil.

Meanwhile, people under the age of 18 were banned from using solariums in France, Spain, Portugal, Germany, Austria, Belgium, the UK, and parts of Australia, Canada and the US.

These laws should be linked to warnings by health professionals and educators about the risks of indoor tanning, the researchers wrote in an editorial in the same edition of the journal.

"Young people in particular should be made aware that the use of sunbeds for short-term cosmetic tanning carries the long-term price of an increased risk of skin cancer," they said.

US expert Simon Williams of Chicago's Northwestern University suggested the European Union should follow the US and introduce a tax on indoor tanning services to acknowledge that like tobacco, tanning is a carcinogen.

Indoor tanning is considered a class I carcinogen by the World Health Organisation.

The current study, led by Professor Eleni Linos at the University of California San Francisco, reviewed 12 studies including more than 9,000 cases of non-melanoma skin cancer.

Using indoor tanning increased the risk of developing squamous cell carcinoma by 67 per cent and basal cell carcinoma by 29 per cent, compared to never using solariums.

The researchers estimated tanning accounted for 3.7 per cent of basal cell carcinoma and 8.2 per cent of squamous cell carcinoma cases in the US alone.

Exposure to indoor tanning before the age of 25 increased the risk of developing basal cell carcinoma.

The authors said although non-melanoma cancer is rarely not lethal, it carries a considerable disease burden.

New Drug Approved for Advanced Colon Cancer

A new drug has received fast-track approval to treat advanced colon cancer, the Food and Drug Administration announced today (Sept. 27).

The drug, Stivarga, has been approved to treat patients with colorectal cancer that has progressed after treatment and spread to other parts of the body, the FDA said.

The drug, manufactured by Bayer HealthCare Pharmaceuticals, works by blocking several enzymes that promote cancer growth. The FDA said it received a fast-track review designated for drugs that offer major advances in treatment or that provide treatment when no adequate therapy exists.

In a study, patients taking the drug lived about six weeks longer than patients taking a placebo.

"Stivarga is the latest colorectal cancer treatment to demonstrate an ability to extend patients' lives and is the second drug approved for patients with colorectal cancer in the past two months," said Dr. Richard Pazdur, director of the Office of Hematology and Oncology Products in the FDA's Center for Drug Evaluation and Research.

Last month the FDA approved the Sanofi-Regeneron drug Zaltrap for use in combination with a FOLFIRI (folinic acid, fluorouracil and irinotecan) chemotherapy regimen to treat adults with metastatic colorectal cancer.

Colorectal cancer is the third most common cancer in men and in women and the third leading cause of cancer death in men and in women in the United States, according to the Centers for Disease Control and Prevention. More than 143,400 Americans will be diagnosed with colorectal cancer, and 51,690 will die from the disease in 2012, the government estimates.

Stivarga was evaluated in a study of 760 patients with previously treated metastatic colorectal cancer. Patients were randomly assigned to receive Stivarga or a placebo in addition to the best supportive care, which included treatments to help manage symptoms and side effects of cancer. Patients received treatment until their cancers progressed or side effects became unacceptable.

Patients treated with Stivarga and supportive care lived about 6.4 months, compared with five months for patients treated with placebo plus supportive care. Those who received Stivarga experienced a delay in tumor growth for about two months, compared with 1.7 months for patients receiving the placebo.

The Stivarga label warns that severe and fatal liver toxicity occurred in patients treated with Stivarga during clinical studies. The most common side effects reported in patients treated with Stivarga included weakness or fatigue, loss of appetite, hand-foot syndrome (also called palmar-plantar erythrodysesthesia), diarrhea, mouth sores (mucositis), weight loss, infection, high blood pressure, and changes in voice volume or quality (dysphonia), the FDA said.

California Says No To "Gay Cure" Therapy

California is taking the proper steps to ban an extremely controversial form of psychotherapy that was developed to help turn gay teens straight. It will be the first state to have successfully banned the program.

The "gay therapy" practice said to be rarely used but has been backed by certain religious groups. Some Republicans also argue that banning the the program would interfere with parents' rights to provide psychological care for children as they see fit.

'One of our number one priorities in this house is to protect the next generation of Californians,' Mr Lara Democrat Ricardo Lara said, one of several openly gay legislators to champion the bill during a debate.

CBS News reports:
Effective Jan. 1, the state will prohibit what is known as reparative or conversion therapy for minors. Brown says the therapies "have no basis in science or medicine and they will now be relegated to the dustbin of quackery." Gay rights groups say the practice is dangerous because it can put youth at higher risk of depression and suicide.

How do you feel about "gay therapy"?

Wal-Mart program offers discounts for healthy food

Wal-Mart Stores Inc. is teaming up with health insurer Humana Inc. to get consumers to buy more healthy foods.

The big-box retailer said Wednesday that it will give eligible shoppers a 5 percent discount on groceries including fruit, vegetables and low-fat dairy products starting next month. The program will be available to shoppers who are covered by Humana insurance and enrolled for its HumanaVitality health program. The companies say there are currently more than 1 million members who are eligible.

The healthy food program starts Oct. 15 at Walmart stores.

The discount will be loaded onto cards as Walmart store credits that shoppers can use on future trips.

Eligible foods, which also include eggs, wheat bread and almonds, will be marked with a "Great For You" icon.

The company said it was continuing an effort begun last year to make healthier food more accessible. It had announced a plan to lower salts, fats and sugars in thousands of the products it sells, and agreed to cut produce prices by 2015.

Wal-Mart, based in Bentonville, Ark., did not disclose the terms of its agreement with Humana, which is based in Louisville, Ky.

Sexy Men Reign At Cosmo Bachelor Bash 2012

Despite the stormy weather that drenched the metro, hundreds still trooped to the World Trade Center on Tuesday to witness the annual feast of perfectly chiseled bodies sashaying on the runway that is the Cosmo Bachelor Bash.

Touted as the ultimate "boyfriend buffet," beauty and fashion magazine Cosmopolitan had once again gathered 69 of the hottest men in the country for a night filled with killer abs, killer smiles, and killer screams.

Turning the heat up at the jampacked venue were topless, hunky popular and budding actors, notable athletes, and ravishing models who took on different roles for this year's theme Cosmo Men Unite.

The first celeb to come out and elicit a torrent of loud frenzied screams from the scintillated crowd was Brapanese model Daniel Matsunaga, who came out with only his pants on which he eventually stripped off to reveal his black shorts.

Young actor Rocco Nacino channeled his inner Channing Tatum from the film "Magic Mike" as he swept the floor with his wicked dance moves which prompted the crowd to cheer like crazy. After his performance, he took off his polo and picked a lucky girl from the attendees and asked her to put her hand on his chest.

Philippine Azkals member Anton del Rosario sizzled onstage as he poured water on his body before taking on the ramp, followed by his teammates Aly Borromeo, Simon Greatwich, Nate Burkey, and Jonah Romero.

"Pinoy Big Brother Double Up" alumni Tom Rodriguez also showed off his muscular body even as Enzo Pineda did some crunches to tease the crowd.

Philippine Volcanoes Rugby Team members Andrew Wolff and Eric Tai, who have been constant figures in the yearly bash, showed they still have the "it factor" with the latter even showing off some break dancing moves and capping it off with a headstand.

Cosmo centerfolds Joseph Marco, collegiate basketball players Anthony and David Semerad, singer Markki Stroem, Century Tuna Superbods grand winner John Spainhour, model-turned-actor Mikael Daez, and model Ian Batherson also had their share of the spotlight.

But the show shockers were first timers actors Alden Richards and JM de Guzman, who both seemed very much ready to cross over to the "manly" side from being flat-out boy-next-doors.

Richards' months of hard work and intense diet to gear up for the event clearly paid off as he showed off his improved torso before shrugging off his pizza delivery boy costume.

Unfortunately though, Cosmo Men supplement coverboy Paulo Avelino wasn't able to walk the ramp this year due to prior commitments abroad for his Kapamilya show "Walang Hanggan."

Obesity more common among rural residents than urban counterparts, study finds

A new study finds that Americans living in rural areas are more likely to be obese than city dwellers. Published in the National Rural Health Association's Fall 2012 Journal of Rural Health, the study indicates that residential location may play an important role in the obesity epidemic.

Led by researchers at the University of Kansas, the study analyzed data collected by the National Center for Health Statistics and is the first in more than three decades to use measured heights and weights. Previous studies have relied on self-reported data, which typically underestimate the prevalence of obesity.

Christie Befort, Ph.D., assistant professor of preventive medicine and public health at the University of Kansas Medical Center, believes there may be two significant reasons why rural residents are more likely to be overweight: cultural diet and physical isolation.

"There is a definite cultural diet in rural America, full of rich, homemade foods including lots of meat and dessert," said Befort, who led the study. The study, which also examined demographic and lifestyle factors, found that rural Americans typically consume a diet higher in fat.

Rural residents also face challenges to accessing health care, prevention and lifestyle activities.

"Access is often about travel time in a rural area, but it can also be that there's no place to go -- literal physical isolation," said Befort. "It's tough to get to a gym if you live outside of a town without one."

The research demonstrated that the rural-urban obesity disparity existed in younger Americans, ages 20-39, but not in older age groups. Befort believes this can be partially attributed to increased mechanization of previously labor-intensive jobs.

"Physical activity is now needed to compensate for diet and technology," said Befort. "That requires cultural change because rural areas typically don't have a culture of physical activity as leisure time."

Befort examined several factors which are thought to affect obesity, including diet, physical activity, age, race, gender, and education. The researchers discovered that even when other contributing factors are held constant, rural residents were more likely to be obese.

"Living in a rural area isn't always recognized as a category for obesity-related health disparities but, according to our study, it should be," said Befort.

"We simply cannot ignore the link between obesity and poverty, and the disproportionate impact this is having on rural America," said Alan Morgan, the National Rural Health Association's CEO. "If we truly want to decrease health care costs and improve the nation's health status, we are going to have to start viewing obesity as a top-tier public health concern for rural Americans."

FULL VIDEO: Victoria's Secret Fashion Show 2011

It's that time of year again! The annual Victoria's Secret Fashion Show is back and sexier than ever. Click through to see the Angels at their finest ... Miranda Kerr dons her $2 million bra for a memorable strut during the show.


A nonantibiotic approach for treating urinary tract infections

The latest episode in the American Chemical Society's (ACS') award-winning Global Challenges/Chemistry Solutions podcast series describes a potential new approach for treating urinary tract infections (UTIs) — which affect millions of people annually — without traditional antibiotics. Because it involves non-antibiotic compounds, the approach would not contribute to the growing problem of antibiotic-resistant bacteria, or "superbugs."

Based on a report by Beat Ernst, Ph.D., and colleagues in ACS' Journal of Medicinal Chemistry, the new podcast is available without charge at iTunes and from www.acs.org/globalchallenges.

In the podcast, Ernst explains that antibiotics are the mainstay treatment for UTIs. Bacteria, however, are developing resistance to common antibiotics, with the emergence of superbugs that shrug off some of the most powerful new antibiotics.

Thus, the scientists decided to try a new approach — developing substances that target bacteria virulence factors, inhibiting them from sticking to the inside of the urinary bladder. Hence, microbes are not able to launch an infection. In addition, this new class of antimicrobials is expected to have a reduced potential for the emergence of resistant microbes.

The scientists describe the development of anti-adhesion molecules that specifically interfere with the attachment of bacteria to human bladder cells. The most potent of the substances prevented a UTI from developing in mice (stand-ins for humans in this kind of experiment) for more than eight hours. In the in vivo treatment study, a very low dose reduced the amount of bacteria in the bladder of the animals by almost 10,000 times, which is comparable to the standard antibiotic treatment with ciprofloxacin.

Global Challenges/Chemistry Solutions is a series of podcasts describing some of the 21st century's most daunting problems, and how cutting-edge research in chemistry matters in the quest for solutions. Global Challenges is the centerpiece in an alliance on sustainability between ACS and the Royal Society of Chemistry. Global Challenges is a sweeping panorama of global challenges that includes dilemmas such as providing a hungry and thirsty world with ample supplies of safe food and clean water, developing alternatives to petroleum to fuel society, preserving the environment and ensuring a sustainable future for our children and improving human health.

For more entertaining, informative science videos and podcasts from the ACS Office of Public Affairs, view Prized Science, Spellbound, Science Elements and Global Challenges/Chemistry Solutions.

The American Chemical Society is a nonprofit organization chartered by the U.S. Congress. With more than 164,000 members, ACS is the world's largest scientific society and a global leader in providing access to chemistry-related research through its multiple databases, peer-reviewed journals and scientific conferences. Its main offices are in Washington, D.C., and Columbus, Ohio.

Natalie Portman shows her flirty side in seductive new Miss Dior Perfume ad

The stunning actress is seen soaking in a bathtub wearing nothing but her Dior sunglasses, passionately kissing and undressing her on-screen lover in the clip.

The advert pays tribute to the 1960s movies of Jean Luc Godard and is set to the famous song Je t'aime...moi non plus by Serge Gainsbourg and Jane Birkin, which adds to the sultry vibe.

In it, the 31-year-old also dons a strapless little black dress, pairing this with a black bowtie which she suggestively unties while staring seductively at the camera.

However sexy the new ad may appear, however, Natalie told Women's Wear Daily that her co-star made her feel 'like an old cougar'.

She said: 'He's, like, 20.'

Despite being the face of one of the most successful fashion brands in the world, Natalie confessed in a recent interview with InStyle that she never feels that she looks perfect enough.

She said: 'My grandmother believes you don't leave the house unless you have perfect hair and make-up, so she is always at me for not brushing my hair or not putting on enough make-up.'

Natalie Portman: Fashion Is 'Surreal'

Actress Natalie Portman still isn't used to being fitted with extravagant haute couture dresses and thinks the fashion industry is very ''surreal''.

Natalie Portman says fashion has given her some ''surreal'' moments.

The 31-year-old actress - who wed French choreographer Benjamin Millepied in August after meeting on the set of 'Black Swan' in 2009 - thinks one of the strangest moments of her life was being fitted for an haute couture gown in the middle of Benjamin's family home.

Natalie told British ELLE magazine: ''Fashion has put me in some strange situations. I was being fitted for a Christian Dior couture dress last year at my husband Benjamin Millepied's house.

''His whole family were sitting there, just having a cup of tea, while all these amazing artisans worked around me to create this absolute incredible dress, that was pretty surreal.''

The brunette beauty is widely admired for her classic and elegant look, but admits it's fun to take fashion risks and make drastic changes to her appearance if a film role requires it.

The mother-of-one enthused: ''I make many sacrifices for my job - if I'm in a period film, I know I can't be a certain shape because I need to be able to adapt to the costume.

''It is a lot of fun as an actor to be able to disguise yourself, like shaving my head in 'V for Vendetta'. It's good to surprise people and to be different from what they expect you to be.''

The Oscar-winning actress also confessed that she models her look on quirky film director Sofia Coppola.

She gushed: ''My style crush is Sofia Coppola, for sure. When I was younger, I thought she was the coolest person ever and I basically tried to copy everything she wore - from her sandals to even her nail colour.''

German women's magazine rethinking 'no models' policy

One of Germany's top women's magazines said Monday it was reviewing its policy of only publishing photographs of amateur models instead of professionals.

The fortnightly magazine, Brigitte, made international headlines in October 2009 with the news that it would only print pictures of "real women" after readers complained they could not identify with ultra-thin professional models. A spokeswoman for Gruner + Jahr publishing house told AFP that a new editor-in-chief planned a thorough overhaul of the magazine, confirming a report in the daily Sueddeutsche Zeitung.

"Everything is under review, including the 'no models' policy," the spokeswoman said, but declined to provide further details until the new editor, Stephan Schaefer, and his co-chief settled on a strategy.

The first "no models" issue hit newsstands in January 2010. It prompted German designer Karl Lagerfeld to call the policy "absurd" and point out that fashion was all about "dreams and illusions".

The Sueddeutsche said one reason for questioning the policy was that lay models were harder for photographers and stylists to work with, while according to Brigitte the amateurs received pay "comparable" to that of professionals.

In addition, the magazine, which was founded in 1954, had to search for women to feature without the help of modelling agencies, also driving up costs.

And many readers complained that while the women in the pages of Brigitte may not be models, they tended to be as thin and pretty as the professionals and the magazine continued to prominently feature diet tips.

The Sueddeutsche report cited figures showing that sales had dropped to around 602,000 from about 802,000 in 2002 with little sign of a boost from the "no models" policy.

The Gruner + Jahr spokeswoman could not immediately confirm the numbers.